Mutational Meltdown in Large Sexual Populations

نویسنده

  • A. Bernardes
چکیده

When a new mdividual is formed (independently of the reproduction process) it inherits harmful iuutations. Moreover, new mutations are acquired even in the genetic code formation, most of them deleterious ones. This might lead to a time decay in the mean fitness of the whole population that, for long enough time, ,vould produce the extinction of the

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Mutational meltdown in laboratory yeast populations.

In small or repeatedly bottlenecked populations, mutations are expected to accumulate by genetic drift, causing fitness declines. In mutational meltdown models, such fitness declines further reduce population size, thus accelerating additional mutation accumulation and leading to extinction. Because the rate of mutation accumulation is determined partly by the mutation rate, the risk and rate o...

متن کامل

Quantifying the mutational meltdown in diploid populations.

Mutational meltdown, in which demographic and genetic processes mutually reinforce one another to accelerate the extinction of small populations, has been poorly quantified despite its potential importance in conservation biology. Here we present a model-based framework to study and quantify the mutational meltdown in a finite diploid population that is evolving continuously in time and subject...

متن کامل

The mutational meltdown in asexual populations.

Loss of fitness due to the accumulation of deleterious mutations appears to be inevitable in small, obligately asexual populations, as these are incapable of reconstituting highly fit genotypes by recombination or back mutation. The cumulative buildup of such mutations is expected to lead to an eventual reduction in population size, and this facilitates the chance accumulation of future mutatio...

متن کامل

The panda and the phage: compensatory mutations and the persistence of small populations.

M utation is the ultimate source of all the genetic variation necessary for evolution by natural selection; without mutation evolution would soon cease. Unfortunately, this comes at a cost: most mutations that affect fitness are deleteri-ous 1. For most large sexual populations, these less fit alleles are eventually eliminated from the population by natural selection. In small populations, howe...

متن کامل

Fitness-dependent mutation rates in finite populations.

Mutation rate may be condition dependent, whereby individuals in poor condition, perhaps from high mutation load, have higher mutation rates than individuals in good condition. Agrawal (J. Evol. Biol.15, 2002, 1004) explored the basic properties of fitness-dependent mutation rate (FDMR) in infinite populations and reported some heuristic results for finite populations. The key parameter governi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2016